$100M yeKugadzira Antibody Kurapwa kweZvirwere Zvakaoma uye Zvisingawanzo Kudzivirirwa

Dianthus Therapeutics nhasi yakazivisa kupedzwa kweiyo $100 miriyoni Series A mari inotungamirwa ne5AM Ventures, Avidity Partners, uye Fidelity Management & Research Company, nekutora chikamu kubva kune vamwe vanoisa mari vanosanganisira Wedbush Healthcare Partners uye vanotanga vatengesi Fairmount, Tellus BioVentures, uye Venrock Healthcare Capital Partners. . Mari iyi ichashandiswa kuwedzera hutungamiri nezvikwata zvesainzi, kufambisira mberi chirongwa chekambani, DNTH103, kuenda kukiriniki gore rino, uye nekumhanyisa zvirongwa zvekuwanikwa kwepombi kune vanhu vanorarama nezvirwere zvakakomba uye zvisingawanzo kurwa ne autoimmune. DNTH103 ine simba, chizvarwa chinotevera monoclonal antibody iyo inosarudza yakananga iyo inoshanda fomu yekuwedzera maC1s, inogona kugonesa yakaderera dosing vhoriyamu uye isingawanzo diki subcutaneous manejimendi inowedzerwa nehafu yehupenyu yekuwedzera tekinoroji. 

Dianthus akazivisawo kugadzwa kwaMarino Garcia seMutungamiriri uye Chief Executive Officer, vachijoinha muna Mbudzi 2021, uye Simrat Randhawa, MD, MBA, seChief Medical Officer. VaGarcia, nyanzvi yezvekutengesa zvinhu uye nyanzvi, inounza makore anopfuura 25 eruzivo rwemabhizimisi mukusimudzira bhizinesi uye mabasa ehutungamiri hwekushanda pamakambani epamusoro ebiotech uye pharma, nguva pfupi yapfuura seMutevedzeri Mukuru weMutungamiri, Corporate uye Business Development ku Zealand Pharma. Dr. Randhawa anounza makore anopfuura 20 ekiriniki yekudzidzira uye ruzivo rweindasitiri yemishonga kuDianthus, kusanganisira mabasa ehutungamiri epamusoro akatarisana munzvimbo dzeautoimmune uye dzisingawanzo zvirwere. Nguva pfupi yadarika akashanda seMutevedzeri weMutungamiriri weKliniki uye Zvekurapa Zvekurapa kuAurinia Pharmaceuticals.

"Takazvipira kusimudzira hupenyu hwevanhu vanorarama nezvirwere zvakakomba uye zvisingawanzo kurwisa zvirwere uye tine chivimbo chekuti masoja ekudzivirira chirwere anogona kuve nemhando yepamusoro yekurapa," akadaro Marino Garcia, Mutungamiriri uye Chief Executive Officer, Dianthus Therapeutics. "Tine rombo rakanaka rekuva neboka rakasimba revanotungamira vanoisa mari mubiotech, nhengo dzeBhodi dzine ruzivo, uye vatungamiri vane ruzivo uye masayendisiti apo tinosimudzira mutungamiri wedu mukiriniki gare gare gore rino, tichienderera mberi nekugadzira pombi yedu yekuwana, uye kuwedzera chikwata chedu mumwedzi iri kuuya. . Dianthus yakamisikidzwa kuve inotungamira, inotevera-chizvarwa kambani inotungamirwa inotungamirwa nekunzwisisa kwakadzama kwezvinodiwa nevarwere. "

Dianthus inoshandisa simba rekusarudza mukugadzirisa nzira dzekugadzira ine simba monoclonal antibodies ine mukana wekukunda zvipingamupinyi zvezvino zvinopindirana therapeutics. Kusiyana neazvino antibody marapirwo anosunga kune ese asingashande uye anoshanda anoenderana mapuroteni, DNTH103 inosarudza inotarisa chete inoshanda fomu yeC1s inoenderana neprotein, ichigonesa yakaderera dosing vhoriyamu uye kushomeka kwekutonga. Iyo hafu-yehupenyu yekuwedzera tekinoroji zvakare inowedzera kuderedza dosing frequency. Nezvimiro izvi zvakasiyana-siyana uye high potency inhibition yeC1s, DNTH103 yakagadzirirwa kubvisa mutoro wepamusoro-soro, kutonga nguva dzose neIV infusions kana kusagadzikana, nguva dzose subcutaneous dosing. Kusimudzira kuvandudzwa kweakanyanya nyore subcutaneous therapy inogona kushandura mukuwedzera vangangove varwere vanogona kubatsirwa kubva mukuwedzera marapirwo, uku ichideredza kusagadzikana uye kukanganisa kwakazara muhupenyu hwevarwere nhasi - pakupedzisira vachibvumira varwere vazhinji kurarama hupenyu hune hutano kusvika hwakazara. zvinogona. 

"Tinodada nekutsigira Dianthus Therapeutics mukusimudzira kuwanikwa nekuvandudzwa kwechizvarwa chinotevera, chine simba, uye chakasiyaniswa zvakanyanya neanorwisa maantibody anowedzera therapeutics," akadaro Paula Soteropoulos, Bhodhi Director weDianthus uye Strategic Advisor ku5AM Ventures. "Nehutungamiriri hweMutungamiriri achangogadzwa uye CEO Marino Garcia, uye nechikwata chine tarenda chevakuru vebiotech uye vezvemabhizinesi vane ruzivo rwakakura rwebudiriro, tinotarisira kuona Dianthus ichiunza kurapa kwavo kuvarwere vanorwara zvakanyanya uye zvisingawanzo. autoimmune zvirwere."