Genegoggle iri kuburitsa chromatin yemuviri zvivakwa (3D DNA kupeta) yemasero anotorwa kubva kune diffuse intrinsic pontine gliomas (DIPG). Iri basa razvino rakanangana nekutsvaga DNA-DNA yekusangana iyo inogona kushandiswa sesero mhando mamaki kuratidza masero eDIPG uye sechinangwa chekuendesa zvinodhaka. Michał Marzęcki, Chief Technical Officer, akazivisa kuti "ichi chimwe chiitiko chakakosha chinosimbisa chokwadi chemhinduro yedu uye kuwedzera kukosha kwedu".
Chimwe chezviratidzo zveDIPG ndeyekuchinja mu histone H3.3 inotungamirira kukuchinja kweamino acid lysine kune methionine (K27M), iyo inokonzera epigenetic maitiro. Genegoggle yakabudirira kuona akawanda eDNA-DNA contacts (aka DNA loops) akasarudzika kune DIPG maseru anotakura K27M mutation uye shanduko muH3K27me3 mbiri kana ichienzaniswa neyakajairwa maseru. Nekushandisa yekucheka-kumucheto epigenetic tekinoroji, mazhinji eaya DNA zvishwe zvakabatanidzwa nekusiyanisa gene kutaura uye kusiyanisa chromatin kuwanikwa.
"Izvi zvawanikwa zvinotizivisa nezve akati wandei histone modification profiles kutsanangura chromatin nyika dzeDIPG maseru zviri nani, izvo zvinotitendera kuona hunhu hutsva uye tarisiro yekiriniki," akadaro Jakub Mieczkowski, PhD, uye Chief Executive Officer. Iyo data yakawanikwa panguva yekubatana kweIllumina Accelerator uye nekubatana naProf. Jacek Majewski kubva kuMcGill University. Paakabvunzwa nezveramangwana reGenegoggle, Chief Business Officer Marcin Kruczyk, PhD, akati, "tinotenda kuti takamisikidzwa zvakasimba kuchikamu chinotevera chekutsvaga mari kuti tienderere mberi nerwendo urwu".
Nezve diffuse intrinsic pontine glioma (DIPG)
Diffuse intrinsic pontine glioma ndiyo inonyanya kuzivikanwa mhando yevana vegomarara reuropi. Kupona kwepakati kwevana vane DIPG hakusviki gore kubva pakuongororwa, uye kuvandudzwa kushoma mukupona kwave kuwanikwa mumakumi emakore. Nzira yemazuva ano yekuongorora ndeyeMRI kuongorora (magnetic resonance imaging) uye inowanzoitika kana zviratidzo zvasvika. Mucherechedzo we genetic weDIPG shanduko mujena H3F3A inokodha histone H3.3.