Medical cannabis inoderedza opioid inoshandiswa kune varwere vane kurwadziwa kusingaperi

Kupa varwere vane chirwere chisingaperi chemarwadzo ekudzokera shure uye osteoarthritis (OA) kuwana cannabis yekurapa kunogona kuderedza kana kutobvisa kushandiswa kwemaopioid ekugadzirisa marwadzo, maererano nezvidzidzo zviviri zvakaratidzwa pa2022 Annual Meeting yeAmerican Academy of Orthopedic Surgeons (AAOS). Zvichitungamirirwa naPrincipal Investigator Asif M. Ilyas, MD, MBA, FAAOS, zvidzidzo zvakaratidzawo kuti marwadzo uye mararamiro ehupenyu zvakavandudzwa mushure mokunge varwere vapiwa zvitupa zvekurapa cannabis.     

Mamirioni makumi mashanu vekuAmerica vanotambura nekurwadziwa kusingaperi kusingaenderane nekenza, iyo inowanzobatwa neopioid. Zvisinei, panodiwa mamwe marapiro. Muna 2019, inofungidzirwa kuti 10.1 miriyoni vanhu vane makore gumi nemaviri kana kupfuura vakashandisa opioid zvisizvo muna 12, ii uye kupindwa muropa neopioid kunoramba kuri pamusoro-nguva. Kushandiswa kwecannabis yekurapa kwakatsvagirwa seimwe nzira yekurapa maopioid, asi zvimwe zvidzidzo zvinodiwa kuti uongorore kushanda, dosing, uye kuti ingakanganisa sei kushandiswa kweopioid pakutarisira marwadzo.

"Mukugadzirisa dambudziko remazuva ano opioid, tinofanira kuona dzimwe nzira dzinogona kuderedza kuvimba neopioid yekudzora marwadzo," akadaro Dr. Ilyas, mutungamiri wepurogiramu yeruoko nepamusoro pekuvhiya kushamwaridzana paRothman Orthopedic Institute uye purofesa wekuvhiyiwa kwemapfupa. kuThomas Jefferson University Hospital muPhiladelphia. "Parizvino, hatisi kukurudzira kushandiswa kwecannabis yekurapa kana kuti inzira iri nani, asi zvidzidzo zvedu zvinoratidza kugona."

Kushandiswa Kwekurapa Cannabis muKurwara Kwekudzokera Kunorwadza uye Varwere veOA

Zvidzidzo zviviri izvi zvakaongorora dhata yeakazadzwa opioid mishonga yakazadzwa kune varwere vane kurwadziwa kusingaperi kwemusana uye OA vakabvumidzwa kuwana cannabis yekurapa pakati paFebruary 2018 naChikunguru 2019. Avhareji morphine milligram equivalents (MME) pazuva remirairo yeopioid yakazadza mwedzi mitanhatu isati yasvika. kune cannabis yekurapa yakafananidzwa nemwedzi mitanhatu mushure mekunge varwere vawana mukana.

Iyo isingaperi musculoskeletal isiri-kenza yekudzokera shure data yakaratidza:

• Kudzikira kukuru kweavhareji yeMME pazuva mushure mekunyorerwa kwecannabis yekurapa, kubva pa15.1 kusvika 11.0 (n=186).

• 38.7% yevarwere yakadzikira kusvika zero MME pazuva.

• Varwere vakatanga vari pasi pe15 MME pazuva uye vanopfuura 15 MME pazuva vane kuderera kukuru, kubva ku3.5 kusvika ku2.1 (n = 134) uye 44.9 kusvika 33.9 (n = 52). Zvikamu zvevarwere vakadonha kusvika zero MME pazuva mumapoka aya aive 48.5% uye 13.5%, zvichiteerana.

• Zvichienzaniswa nekutanga (mwedzi mitatu, mitanhatu, uye mipfumbamwe), varwere vakarondedzera kuvandudzwa kwesimba, kuwanda, uye zuva nezuva basa mushure mekushandisa cannabis yekurapa.

• Varwere vakashandisa nzira mbiri kana kupfuura dzehutungamiri kune cannabis yezvokurapa vakaratidza kuderera kukuru kweMME pazuva, kubva ku13.2 kusvika ku9.5 (n = 76).

Kurapwa kweOA, matanho emhedzisiro yemurwere akaongororwa pamwedzi mitatu, mitanhatu, uye mipfumbamwe zvichitevera kushandiswa kwecannabis yekurapa. Mushure mekuwana cannabis yekurapa, chidzidzo chakaratidza:

• Pakave nekuderera kukuru muvhareji yeMME pazuva rezvinyorwa zvakazadzwa nevarwere, kubva ku18.2 kusvika ku9.8 (n = 40). Avhareji yekudonha kweMME pazuva yaive 46.3%.

• Huwandu hwevarwere vakadonha kusvika pazero MME pazuva hwaive 37.5%.

• Matambudziko evarwere akaderera zvakanyanya, kubva ku6.6 (n = 36) kusvika ku5.0 (n = 26) uye 5.4 (n = 16), pamwedzi mitatu nemitanhatu, maererano.

• The Global Physical Health yehutano hwehupenyu hwehupenyu hwakawedzera zvakanyanya, kubva pa37.5 kusvika ku41.4, pamwedzi mitatu.

"Zvidzidzo zvedu zvinoratidza kuti cannabis yezvokurapa inogona kuva mushonga unoshanda kune kusingaperi kurwadziwa kwemusana uye osteoarthritis, zvinogona kubatsira kuderedza kuvimba nemaopioid," akadaro Dr. Ilyas. "Zvisinei, tsvakiridzo yakawedzerwa inodiwa kuti unzwisise zviri nani nzira dzakanakisa uye mafambiro, zvinogona kuitika zvakashata, uye mhedzisiro yenguva refu yekushandiswa kwecannabis yekurapa. Panguva ino, vanyoreri vanofanirwa kushandisa sarudzo dzakagovaniswa nevarwere vavo kana vachifunga nezve cannabis yekurapa yeasingaperi musculoskeletal kurwadziwa mamiriro. "