Kuonekwa kweCancer: Nzira itsva isina-invasive

Masayendisiti kubva kuSwiss-Austrian research group HealthBiocare GmbH uye System Biologie AG, pamwe nekubatana neYunivhesiti yeVienna, vakawana nzira nyowani isiri-invasive yekuona mhando pfumbamwe dzegomarara.

Kunyangwe gomarara riri iro riri kukonzera kufa kwevanhu pasi rose, hapasati pave nemakiriniki akabvumidzwa bvunzo dzekuongororwa gomarara kwehuwandu hwevanhu. Mapundu ekare anoonekwa, gomarara rinokurumidza kudzivirirwa kana kuti mikana yekurapwa inowedzera.

Nekubatanidza DNA mutations ne epigenetic alterations senge DNA methylation uye miRNAs, masayendisiti akagadzira mhando yemhando inogona kusiyanisa pakati pezvidzidzo zvine hutano nevarwere vane mamota akasimba ane 95.4% accuracy, 97.9% senitivity, uye 80% chaiyo.

Kazhinji, vaongorori vazhinji vanotarisa pane imwe biomarker, uye imwe kenza mhando panguva. Pachidzidzo ichi, masampuli eplasma ezvidzidzo zvine hutano uye vanhu vane imwe yemhando pfumbamwe dzakasiyana dzakaongororwa genetics uye epigenetics alterations (mapapu, pancreas, colorectal cancer, prostate, ovarian, zamu, dumbu, dundira, uye kenza yeuropi). Kusanganiswa kwevaongorori vatatu vakasiyana kwakaratidza kunyatsojeka uye kunzwisiswa uye kwaive kwepamusoro kune iyo biopsy modhi yakavakirwa chete pakuchinja, cfDNA methylation, kana miRNAs.

Kunyatso simbisa kushanda kwekiriniki kwebvunzo iyi uyezve kuongorora kana matishu ekwakabva angaonekwa, vaongorori vanoronga kuita boka rakakura rinotarisirwa. Chinangwa chavo chikuru ndechekugadzira iyo chaiyo, yakapusa uye isinganyanyi kupindira pan-cancer yekuongorora bvunzo iyo inogona kuitwa nguva nenguva pakuongororwa kwepagore, nekudaro vachiwedzera kuonekwa kwebundu kwekutanga, kunyanya muhuwandu hwenjodzi.