Kwangopera gore rimwe chete mushure mekubudirira kuratidza kugadzirwa kwelab-scale ye insulin yemunhu vachishandisa nzira dzekugadzira biology, rBIO ichangobva kupedza chirongwa chebudiriro neWashington University muSt.
rBIO, yekutanga-danho rekugadzira biology kambani yakatarisana nekudzikisa mutengo wekuwedzera kudhura biologic therapies, yakazivisa kunatsiridzwa kweiyo mabhakitiriya-based kugadzirwa kwe insulin. rBIO's synthetic kugadzira process ikozvino inopa zvakapetwa kaviri vhoriyamu ye insulin kana ichienzaniswa nenhaka recombinant kugadzira matekiniki uye inoisa kambani yekushambadzira-mwero kugadzirwa kwe insulin uchishandisa proprietary process yakagadzirwa mukubatana neWashington University muSt.
Kugadzirira uku kwezvinzvimbo zvemusika rBIO yeprotein remangwana uye peptide pombi mukwikwidzi kusimudzira nekugadzira. Munguva pfupi, rBIO ichapinda mumusika nekukurumidza kupfuura zvanga zvichitarisirwa uye ichawana kupinda nechinangwa chekudzikisa mutengo wemishonga insulin nechikamu chimwe muzvitatu.
rBIO yakabatana pachirongwa ichi chekutsvakurudza nekusimudzira neWashington University muSt. Louis, boka rinotungamirirwa naDr. Sergej Djuranovic, purofesa wemubatanidzwa we cell biology uye physiology paChikoro cheMishonga cheyunivhesiti.
Mugore rapfuura, Chikwata chaDr. Djuranovic chakatarisana nekugadzirisa uye kuwedzera maitiro evaridzi anoshandisa budiriro ichangoburwa mujenetics uye synthetic biology sainzi kugadzira mhando nyowani dzemabhakitiriya akagadziridzwa anokwanisa kuratidza akasiyana mahomoni epeptide. Pakutanga, murabhoritari yaDr. Djuranovic yakanga yawana macoding motifs aishandiswa kuderedza kutaura kwemamwe mapuroteni ari mumasero egomarara. Chikwata chakawedzera basa iri rekutanga: kutarisa kuti anologous motifs anogona sei kuwedzera kutaura - nekudaro ichimhanyisa rBIO mukuda kwayo kuwedzera goho remishonga.
“Kugadzirwa kwemapuroteni akasanganiswa kwagara kwakaoma, kuchidhura, uye kuchidya nguva. Kukwanisa kuratidza mhedzisiro iyi kunovhura mukana wekuwedzera goho rekugadzira uye kutyaira pasi mutengo wemamwe mapuroteni emishonga, "akadaro Dr. Djuranovic. "Takatanga tsvakiridzo mune mamwe mamorekuru ekufarira anogona kuvhura musuwo kune mamwe verticals kuwedzera kumahomoni epeptide akadai se insulin."
“Chikwata chakapedza gore chichiona kuti imarii yatinogona kuwedzera goho nekutyaira yakakwira ye insulin. Isu tinofara kuzivisa kuti maitiro edu ave kupa insulin yemunhu zvakapetwa kaviri chiyero chemaitiro enhaka, "akadaro microbiologist Cameron Owen, CEO uye co-muvambi werBIO. "Nerudzi urwu rwesimba rezvipenyu, isu tine shungu dzekukwira nekutanga kugadzirwa kwemaindasitiri - uye kuita kuti hormone iyi iwanikwe nemutengo wakaderera kumamirioni evaAmerica vane chirwere cheshuga."
ZVOKUBVA MUNYAYA INO:
- rBIO's synthetic kugadzira process ikozvino yave kupa zvakapetwa vhoriyamu ye insulin kana ichienzaniswa nenhaka recombinant kugadzira matekiniki uye inoisa kambani kushambadzira-mwero kugadzirwa kwe insulin ichishandisa proprietary process yakagadziridzwa mukudyidzana neWashington University kuSt.
- Chikwata chaDjuranovic chakatarisana nekugadzirisa uye kukwirisa maitiro evaridzi ayo anoshandisa budiriro ichangoburwa mujenetics uye synthetic biology sainzi kugadzira mhando nyowani dzemabhakitiriya akagadziridzwa anokwanisa kuratidza akasiyana mahomoni epeptide.
- Munguva pfupi, rBIO ichapinda mumusika nekukurumidza kupfuura zvanga zvichitarisirwa uye ichawana kupinda nechinangwa chekudzikisa mutengo wemishonga insulin nechikamu chimwe muzvitatu.
