Avion Pharmaceuticals, LLC, kambani yeAlora Pharmaceuticals, yakazivisa kutengeswa kweDHIVY, yekutanga uye yega carbidopa/levodopa (CD/LD) piritsi rechikamu rakagadzirirwa kugoverwa. Avion yakawana mvumo yeDHIVY kubva kuFDA muna Mbudzi 2021. Iyi dhizaini yakasarudzika inogonesa kurongeka kwemishonga uye inogadzirisa zvakananga kudiwa kwemusika kubatsira mukutsikisa goridhe chiyero chinowanzoshandiswa neavo vane Parkinson's Disease (PD), iyo inokurumidza kukura yetsinga. mamiriro ezvinhu muUnited States, iyo parizvino isina kurapwa.
DHIVY yakagadzirwa nenyanzvi mbiri dzetsinga dzakaona kudiwa kweCD/LD tablet inogona kuve yakasarudzika. Iyo tekinoroji yepiritsi tekinoroji yakagadzirwa neakadzama zvibodzwa zvinoita kuti varwere vagoipatsanura chaizvo kuti ienderane nedosi yavo yakakurudzirwa. Zvikamu zvina zvehwendefa zvine 6.25/25 mg yeCD/LD—dikidiki, chairoiro dosi rinowanikwa pamusika wanhasi. IAmerican Academy of Neurology (AAN) mune yayo yakagadziridzwa nhungamiro yekurapa kwekutanga kwechirwere cheParkinson inokurudzira kutanga varwere vane dhigirii yakaderera inoshanda yekukurumidza-kuburitsa carbidopa/levodopa.
“Kunyatsogadzirisa dhigirii remunhu wega wega CD/LD mukuwedzera kuri pasi pe50 mg yelevodopa hakuna kuvimbika zvakanyanya. Sarudzo yekunyatso uye yakavimbika kupatsanura CD / LD dose mu 6.25 / 25 mg increments inopa vanachiremba nevarwere mukana wenguva yakareba wekuita zviri nani hutungamiri hwePD, "akadaro Dr. Leo Verhagen Metman, MD, Rush University Medical Group. "Izvi zvinogona kubatsira kwete kuvarwere vane brittle chete vanovavarira kufamba munzira ine matombo yekushanduka kwemotokari uye dyskinesia, asiwo kune avo vane chirwere chakakomba vasingadi kutora CD / LD pane zvakanyanya kudiwa."
Kubva 1990 kusvika 2016, mutoro wepasi rose wePD wakawedzera zvakapetwa kaviri. MuUnited States moga, maiva nemamiriyoni 1.04 evanhu vane PD muna 2017, pamwe nekufungidzira kwehuwandu hwevanhu mamiriyoni 1.64 panosvika 2037. Kunyange zvazvo CD/LD iri iyo yegoridhe, uye ndiyo yave iri kutungamira kurapwa kwePD, akawanda CD/LD-yakarapwa. varwere vanorondedzera kuomerwa kubata-off-nguva uye mhedzisiro semhedzisiro yekuomerwa neiyo yakakwana uye chaiyo dosing yemushonga. Izvi zvinogona kutungamirira kumatambudziko akadai sedyskinesia, izvo zvinogona kuitika kana murwere atora CD / LD yakawandisa, kana kuti-episodes-episodes inogona kukonzera kupera kwenguva pfupi.
“Kunyangwe pasina varwere vaviri vane chirwere cheParkinson vakafanana, mutoro unotarisana nevarwere vese wakakura. Avion inofara kuunza DHIVY kumusika kuti ibatsire varwere ava nevanovapa kubata zvirinani zvinodiwa neCD/LD dosing vane ruzivo rwakanyanya, "akadaro Harold "Art" Deas, Chief Executive Officer weAlora Pharmaceuticals. "Iyo dhizaini yepiritsi inopa nzira nyowani yekuisa yega yega dosi uye kudzikisira mamwe ematambudziko anotarisana nevarwere pari zvino kana zvasvika pakubata kwavo mishonga."
ZVOKUBVA MUNYAYA INO:
- Iyi yakasarudzika dhizaini inogonesa yakanyatso dhizaini yemushonga uye inogadzirisa zvakananga kudiwa kwemusika kubatsira mukumisikidzwa kweiyo goridhe chiyero chinowanzo shandiswa neavo vane Parkinson's Disease (PD), iyo inokurumidza kukura mamiriro etsinga muUnited States, iyo parizvino isina. kurapa.
- Nepo CD/LD iri chiyero chegoridhe, uye yanga iri iyo inotungamira kurapa kwePD, varwere vazhinji vakarapwa neCD/LD vanotaura kuomerwa nekutadza kubata-nguva nemhedzisiro semhedzisiro yekunetsekana nekunyatso uye chaiyo dosing yemushonga.
- Avion inofara kuunza DHIVY kumusika kuti ibatsire varwere ava nevanovapa kuti vakwanise kufambisa zvirinani zvinodiwa neCD/LD dosing vane ruzivo rwakanyanya,”.
