KUKURUKURA
Yakakwira SARS-CoV-2 kutapurirana kuri kuitika muChile kunyangwe paine mushandirapamwe wekudzivirira, uyo unonyanya kuvimba nekudzivirira hutachiona husina kuvharwa kubva kuSinovac Biotech uye kusvika padiki mukudzivirira kwemRNA kubva kuPfizer/BioNTech uye isiri-inodzokorora hutachiona hwehutachiona kubva. Oxford/AstraZeneca uye Cansino Biologicals.
Kuvhiya kwekupedzisira kunotaurwa munyika kwaitongwa neSARS-CoV-2 variants Gamma naLambda, iyo yaimbove yakatsanangurwa seyakasiyana yekunetseka mwedzi yakati wandei yapfuura uye iyo yekupedzisira ichizivikanwa nguva pfupi yadarika semusiyano wekufarira neWHO. Nepo iyo Gamma mutsauko iine gumi neimwe shanduko mu spike protein inosanganisira idzo dziri mu receptor-binding domain (RBD) yakabatana nekuwedzera ACE11 kusunga uye kutapukira (N2Y) kana immune kupukunyuka (K501T uye E417K) iyo spike protein yeLambda musiyano ine yakasarudzika. muenzaniso we484 mutations (Δ7-246, G252V, T75I, L76Q, F452S, D490G, T614N) kubva iyo L859Q yakafanana neL452R mutation yakashumwa muDelta neEpsilon zvakasiyana.
Iko kushanduka kweL452R kwakaratidzwa kupa kutiza kwekudzivirira kwemuviri kune monoclonal antibodies (mAbs) pamwe neconvalescent plasma.
Zvakare, iyo L452R mutation yakaratidzawo kuwedzera hutachiona hwehutachiona uye data redu rinoratidza kuti L452Q shanduko iripo muLambda musiyano inogona kupa zvivakwa zvakafanana kune izvo zvinotsanangurwa L452R. Sezvineiwo, iyo 246-252 kudzima muN-terminal domain (NTD) yeLambda Spike iri mune antigenic supersite uye nekudaro, kudzima uku kunogonawo kubatsira mukupukunyuka kwekudzivirira. Uyezve, iyo F490S shanduko yakave yakabatana nekupukunyuka kune convalescent sera.
Zvichienderana neaya antecedents, mhedzisiro yedu inoratidza kuti spike protein yeLambda mutsauko inopa kutiza kwekudzivirira kudzivirira masoja ekudzivirira anokonzerwa neCoronaVac vaccine. Kana iyo Lambda musiyano zvakare inotizira kune cellular mhinduro inoratidzwa kuve yakakurudzirwa neCoronaVac hazvisati zvazivikanwa.
Isu takaona zvakare kuti spike protein yeLambda musiyano yakaratidza kuwedzera kutapukira kana ichienzaniswa neiyo spike protein yeAlpha neGamma akasiyana, ese ari maviri ane kushumwa kwakawedzera kutapukira uye kutapurirana.
Pamwe chete, data redu rinoratidza kekutanga kuti shanduko dziripo muprotein spike yeLambda musiyano inopa kutiza kune masoja ekudzivirira ekudzivirira uye kuwedzera kutapukira. Humbowo hunoratidzwa pano hunosimbisa pfungwa yekuti mishandirapamwe mikuru yekudzivirira majekiseni munyika dzine huwandu hwekutenderera kweSARS-CoV-2 hunofanirwa kuperekedzwa nekunyatsoongorora genomic ine chinangwa chekukurumidza kuona hutachiona hutsva hunotakura spike mutations pamwe nezvidzidzo zvine chinangwa chekuongorora maitiro eizvi. shanduko mukupukunyuka kwekudzivirira uye majekiseni.
COVID-19 iri kufambira mberi nekukurumidza. Izvi zvinogona kuonekwa muHawaii umo nhamba dzaive dzakaderera uye dzakasvetuka kurekodha kumusoro nekushanya kuri kuwedzera.
