Kunyatsoongorora kusagadzikana kwepfungwa kunogona kuve kwakaoma, kunyanya kune vadiki vadiki vasingakwanise kuzadzisa mibvunzo kana zviyero zvekuyera. Dambudziko iri rave rakanyanya muvanhu vashoma vasina kudzidza. Ongororo yapfuura genomic yakawana akati wandei genomic masaini eakasiyana epfungwa kusagadzikana, uye mamwe anoshanda seanogona kurapa zvinodhaka zvinonangwa. Deep kudzidza algorithms akashandiswawo kubudirira kuongorora zvirwere zvakaoma senge kutarisisa deficit hyperactivity disorder (ADHD). Nekudaro, maturusi aya haasati ashandiswa muhuwandu hukuru hwevarwere veAfrica America.

Muchidzidzo chakasiyana, vaongorori vakagadzira data rese regenome sequencing kubva ku4,179 murwere masampu eropa evarwere veAfrica America, kusanganisira varwere 1,384 vakaonekwa vaine chirwere chepfungwa chimwechete. , Autism spectrum disorder, hurema hwepfungwa, kusagadzikana kwekutaura/mutauro, kunonoka mukukura uye kupikisa kupikisa kusagadzikana (ODD). Chinangwa chenguva refu chebasa iri kudzidza zvakawanda nezve njodzi dzakanangana dzekukudziridza zvimwe zvirwere muvanhu vemuAfrica muAmerica uye nzira yekuvandudza mhedzisiro yehutano nekutarisa nzira dzemunhu dzekurapa.

"Zvidzidzo zvizhinji zvinongotarisa pachirwere chimwe chete, uye vanhu vashoma vanga vachimiririrwa zvakanyanya muzvidzidzo zviripo zvinoshandisa muchina kudzidza kudzidza kusagadzikana kwepfungwa," akadaro munyori mukuru Hakon Hakonarson, MD, PhD, Director weCentre for Applied Genomics kuCHOP. . "Taida kuyedza iyi modhi yekudzidza yakadzama muhuwandu hwemuAfrica kuti tione kana ichikwanisa kunyatsosiyanisa varwere vepfungwa kubva kune zvine hutano kutonga, uye kana tichigona kunyora nemazvo marudzi ehosha, kunyanya muvarwere vane kusagadzikana kwakawanda."

Iyo yakadzama yekudzidza algorithm yakatsvaga kuremerwa kwema genomic akasiyana mukodha uye asiri-coding matunhu eiyo genome. Iyo modhi yakaratidza pamusoro pe70% chokwadi mukusiyanisa varwere vane dambudziko repfungwa kubva muboka rekutonga. Iyo yakadzika yekudzidza algorithm yaive yakaenzana mukuongorora varwere vane akawanda kusagadzikana, neiyo modhi ichipa chaiyo yekuongorora machisi mune angangoita gumi muzana emakesi.

Iyo modhi zvakare yakabudirira kuona akawanda genomic matunhu akapfumiswa zvakanyanya nekuda kwekukanganisika kwepfungwa, zvichireva kuti ivo vangangove vakabatanidzwa mukuvandudzwa kwezvirwere izvi zvekurapa. Nzira dzehupenyu dzakabatanidzwa dzaisanganisira dzakabatana nemhinduro dzekudzivirira zvirwere, antigen uye nucleic acid binding, chemokine signing pathway, uye guanine nucleotide-binding protein receptors. Nekudaro, vaongorori vakawanawo kuti akasiyana mumatunhu asina kodhi yemapuroteni airatidzika kunge ane chekuita nekukanganisika uku nepamusoro frequency, zvinoreva kuti vanogona kushanda semamwe mamaki.

"Nekuona mutsauko wemajini uye nzira dzakabatana, tsvakiridzo yeramangwana ine chinangwa chekuratidza basa ravo inogona kupa ruzivo rwemagetsi nezve kuti matambudziko aya anokura sei," akadaro Hakonarson.

Tsvagiridzo iyi yakatsigirwa neInstitutional Development Funds kubva kuCHOP kuenda kuCentre for Applied Genomics neChipatara chevana chePhiladelphia Endowed Chair muGenomic Research.

ZVOKUBVA MUNYAYA INO:

Muchidzidzo chakasiyana, vatsvakurudzi vakagadzira data rese rejenome sequencing kubva ku4,179 varwere veropa revarwere vemuAfrica America, kusanganisira varwere 1,384 vakaonekwa vaine chirwere chepfungwa chimwechete. , Autism spectrum disorder, kuremara kwenjere, kusagadzikana kwekutaura/mutauro, kunonoka mukuitika uye kupikisa kupikisa kusagadzikana (ODD).
"Taida kuyedza iyi modhi yekudzidza yakadzama muhuwandu hwemuAfrica kuti tione kana ichikwanisa kunyatsosiyanisa varwere vepfungwa kubva kune zvine hutano kutonga, uye kana tichigona kunyora nemazvo mhando dzehosha, kunyanya muvarwere vane kusagadzikana kwakawanda.
Chinangwa chenguva refu chebasa iri kudzidza zvakawanda nezve njodzi dzakanangana dzekukudziridza zvimwe zvirwere muvanhu vemuAfrica muAmerica uye nzira yekuvandudza mhedzisiro yehutano nekutarisa nzira dzemunhu dzekurapa.