Chidzidzo chitsva chinoratidza vanopfuura miriyoni imwe vachafa gore rega rega negomarara rechiropa

Sangano reWorld Health Organisation rinoti kutanga muna 2030, vanhu vanodarika miriyoni vachafa gore rega rega negomarara rechiropa. Cold Spring Harbour Laboratory (CSHL) Muzvinafundo Adrian Krainer, aimbove postdoc Wai Kit Ma, naDillon Voss, Stony Brook University MD-Ph.D. mudzidzi-mu-kugara muKrainer's lab, vauya nenzira yekukanganisa nzira yesimba inobvumira gomarara iri kukura nekupararira. Ivo nguva pfupi yadarika vakaburitsa basa ravo, raive mubatanidzwa neIonis Pharmaceuticals, mumagazini Cancer Research.             

Masayendisiti eCSHL akashandisa antisense oligonucleotides (ASOs), ayo ari musanganiswa weiyo genetic code inosunga kuRNA uye inoshandura nzira iyo masero anovaka mapuroteni. Aya mamorekuru anochinja enzyme inoshandiswa nemasero egomarara rechiropa kubva kune imwe mhando yepyruvate kinase protein (PKM2), iyo inowanzoratidzwa muembryonic nekenza maseru, kuenda kune imwe fomu yepyruvate kinase protein (PKM1), iyo inosimudzira bundu-kudzvinyirira maitiro. Kushandura basa repuroteni iyi kunokanganisa nzira iyo masero ekenza anoshandisa nayo chikafu, izvo zvinogona kuderedza kukura kwavo. Sekutsanangura kunoita Krainer, "Chii chakasiyana nezvemaitiro edu ndechekuti tiri kuita zvinhu zviviri panguva imwe chete: tiri kuramba PKM2 uye kuwedzera PKM1. Uye isu tinofunga zvese izvo zvakakosha. "

MaASO ari kuvimbisa gomarara rerudzi urwu nekuti mushure mekuabaya jekiseni pasi peganda, muviri unoaendesa kuchiropa. Gomarara rechiropa raizodziviswa kukura uye kupararira kune dzimwe nhengo. Vatsvagiri vakaona kudzikiswa kwakanyanya mukuvandudzwa kwemamota mumamodhi maviri emakonzo avakadzidza. Chidzidzo ichi chinovakira patsvagiridzo yepakutanga murabhoritari yeKrainer mavakachinja PKM2 kuenda kuPKM1 mumaseru ane tsika kubva kuhutsinye hwegomarara reuropi rinonzi glioblastoma.

Iri zano rine zvakare rimwe bhenefiti, sezvo masero echiropa ane hutano haaite iyo yakafanana RNA iyo ASOs yaizonanga mumaseru egomarara rechiropa. Izvo zvinoderedza mukana wechero off-chinangwa mhedzisiro. Voss anoti, "Kukwanisa kuendesa kurapwa uku kuchiropa, pasina kukanganisa maseru echiropa, kunogona kupa sarudzo inoshanda, yakachengeteka yekurapa gomarara rechiropa mune ramangwana."

Krainer, uyo ari kushanda neantisense oligonucleotides mune zvimwe zvirwere zvinosanganisira cystic fibrosis uye spinal muscular atrophy, anoronga kuramba achishandisa maturusi aya ekurapa kutsvaga nzira dzekurapa gomarara rechiropa. Pakati pemimwe mibvunzo, vaongorori vanotarisira kuongorora kana mamorekuru eRNA anogona kubatsira kuve nemametastases egomarara kuchiropa kubva kune dzimwe nhengo.