Kubudirira Kuberekwazve Kwemakumbo muMatatya Akura uchishandisa Novel Drug Combination

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Morphoceuticals Inc. yakarumbidza mhedzisiro yeongororo yenguva refu yakabudiswa nevatangi vayo muScience Advances inoratidza kubudirira kuvandudzwa kwemakumbo muXenopus laevis (African clawed frog). Ichi ndicho chiratidziro chekutanga chekushanda patsva kwemakumbo mumhando yemhando isingaratidzi kungoerekana yavandudzwa kwemakumbo akaoma muhukuru. Vanosvika 185,000 3.6 kudimburwa gumbo, kuvhiyiwa kwegumbo, kunoitwa muUnited States gore rega rega uye zvinotarisirwa kuti vanhu vangangosvika mamirioni 2050 vachange vachirarama nekurasikirwa neruoko kana gumbo panosvika XNUMX. (Amputee Coalition)

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Michael Levin, Vannevar Bush Purofesa weBiology paTufts University naDavid Kaplan, Stern Family Purofesa weUinjiniya kuTufts ndivo vavambi veMorphoceuticals Inc., vakaratidzira pamwe chete nechikwata chavo: kukurazve, kucherechedzwa kudzokororwa kwetishu, uye kudzoreredza kushanda kweX. laevis hindlimb zvichitevera kuratidzwa kwenguva pfupi, kwemaawa makumi maviri nemana kune riwaya remishonga yakawanda, pro-regenerative kurapwa inounzwa neinopfeka bioreactor. Matishu akagadziridzwa akaumbwa neganda idzva, bhonzo, vasculature, uye tsinga zvakapfuura zvakanyanya kuoma uye sensorimotor masimba ezvinodzora zvechidzidzo.

Levin akataura kuti "Zvipenyu zvakadai se X. laevis, izvo zvisingakwanisi kudzorerazve pakukura zvinoratidzira zvimwe zvezvipingamupinyi zvakakosha zvevanhu, mienzaniso inokosha yekuedza nayo kupindira uye kuwana zvinokonzera zvinogona kudzorera zvose chimiro nekushanda". Kaplan akawedzera "Idzi data dzinoratidza kugona kwedu kubudirira 'kutanga' endogenous regenerative nzira mumhuka dzine vertebrate; zvisinei, kushandurwa kwezviwanikwa izvi kumhuka dzinoyamwisa kunoramba kuchiratidzwa sedanho rinotevera rinokosha mukuita uku”.

Greg Bailey, MD, CEO kuJuvenescence Ltd., mubatsiri wekutanga weMorphocueticals, akati "Dr. Levin naKaplan vari kupayona nzira nyowani dzekugonesa kudzoreredzwa kwenhengo dzinoshanda, matishu, uye nhengo. Izvi zvakawanikwa zvinozivisa kushandiswa kwekutanga kwechitsva chezvishandiso zvitsva zvichave zvichivandudzwa neMorphoceuticals uye zvichatibvumira kuongorora nzira itsva dzekurapa patsva nenzira dzakasarudzika". Akawedzera kuti "Zvikumbiro zvingangoitirwa rimwe zuva kubatsira varwere kukunda mutoro wekurasikirwa nenhengo nemakumbo nenzira dzisingagoneke nemishonga yechivanhu, ndosaka Juvenescence yakaisa mari uye ichiramba ichitsigira papuratifomu yesainzi yeMorphoceuticals."

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Mupepeti mukuru we eTurboNew ndiLinda Hohnholz. Iye anogara muTN HQ muHonolulu, Hawaii.

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