Vashandi vane mukurumbira vekutsvagisa vari kushanda kutenderera nguva kuti vape mafambiro ekuti ungazvichengete sei zvakanaka kana uchifungidzira kuti urikurwara COVID-19 coronavirus.

Zvidzidzo zvekurapa pa COVID-19 zviri kuburitswa pamutsindo, kazhinji zvichikonzera nyonganiso pazvinhu zvakapusa senge marwadzo anotora kutora, kana machengeterwo emitezo yemhuri inorwara pamba.

Kuti uwane nhungamiro, National Geographic yakatendeukira kuna varapi vanotungamira nevatsvaguri kuUS neCanada kune kwavo kurudziro pamusoro pekuchengetwa-mumba, pamwezve nenguva yekutsvaga kurapwa.

Vanachiremba vatanhatu vanotungamira vanotsanangura zvatinoziva kusvika zvino kurapa COVID-19 muimba yekukurumidzira uye kumba.

NZIRA YOKURWISANA NEMHARA

Nhau dzakanaka ndedzekuti angangoita makumi masere muzana ezviitiko zvese zveCOVID-80 zvinoratidza chete zvinyoro kusvika kune zvine mwero zviratidzo zvisingade kuiswa muchipatara. Vanachiremba vanokurudzira kuti varwere ava vazviparadzanise, vagare vakasvinwa, vadye zvakanaka, uye vagadzirise zviratidzo zvavo nepavanogona napo.

Nekuchengetedza fivhiri inosanganisirwa nezvirwere zvakawanda, kusanganisira COVID-19, vanachiremba vanokurudzira kutora acetaminophen-inozivikanwa pasi rese separacetamol-pamberi pe ibuprofen. Kana fivhiri ikaramba iripo, varwere vanofanirwa kufunga nezvekuchinja kuita ibuprofen, anodaro Julie Autmizguine, chiremba wezvirwere zvinotapukira zvevana paCHU Sainte-Justine kuMontreal, Canada.

Iye nevamwe vanachiremba vanotaura izvi nekuda kwekuti ibuprofen nemimwe mishonga inoenderana nayo - inonzi NSAIDs kwenguva pfupi - inogona kuva nemhedzisiro inokuvadza kune avo vanorwara neCOVID-19 coronavirus, kusanganisira kukuvara kwetsvo, maronda emudumbu, uye kubuda kwemudumbu.

Nekudaro, yambiro iyi haireve kuti ibuprofen neNSAID zvinokuvadza mhedzisiro necoronavirus, sevirusi nhau nyaya dzakataurwa svondo rapfuura mushure meFrance Ministry of Health kuti mishonga inofanirwa kudzivirirwa panguva yekurapa kweCOVID-19.

"Handizive kuti maNSAID akaratidzirwa kuva dambudziko rakaipa pachirwere ichi kana kune chero coronavirus," anodaro nyanzvi yecoronavirus Stanley Perlman, chiremba wevana uye immunologist paUniversity yeIowa's Carver College yeMishonga.

Acetaminophen inouyawo nenjodzi, uye vanhu vanofanirwa kuitora chete kana vasina kukanganiswa kana vasina kukuvara kwechiropa. Mushonga uyu wakachengeteka pamitezo yemazuva ese isingasviki zviuru zvitatu zvemamirigiramu, asi kupfuudza huwandu hwezuva nezuva uhwu kunogona kukanganisa kukuvara kwechiropa kana kutonyanya.

"Acetaminophen overdose ndiyo inonyanya kukonzera kukundikana kwechiropa muUnited States," anodaro José Manautou, nyanzvi yezvehupfu paUniversity of Connecticut School of Pharmacy.

Vanhu vanofanirwa kuve nechokwadi chekuzvidavirira pamishonga yese yavari kushandisa, nekuti mishonga yemupamakosi inotarisana nezvirwere zvechirwere uye zvimwe zvinobatsira pakurara zvinowanzove neacetaminophen. Vanhu vanofanirwawo kudzivirira kunwa doro pavanotora acetaminophen. Chiropa chinovimba nechinhu chimwe chete — glutathione — kudzora simba rine chepfu rezvose zviri zviviri doro uye acetaminophen. Kana iwe ukadya zvakawandisa zvese zviri zviviri, zvinogona kukonzera kuti chepfu iungane mumuviri. (Kamwe kana muviri wako watapukirwa, izvi ndizvo zvinoita coronavirus.)

Zvakadiniko Nezve CHLOROQUINE NEAZITHROMYCIN?

Zvikwata zvekurapa zviri kushanda zvisingamire kuti dzizive marapirwo akanaka eECOVID-19, uye muvhiki rapfuura, Mutungamiri weUS Donald Trump akabatana nekurwira nekutaura rutsigiro rwake rwemishonga miviri yakavapo kwemakumi emakore - antibiotic azithromycin, uye vhezheni ye iyo antimalarial drug chloroquine.

Muchokwadi, iyo US Chikafu neDrug Administration haina kubvumidza hydroxychloroquine-inowanzo shandiswa kurapa rheumatoid arthritis uye lupus - kuti ishandiswe neCOVID-19, kunyangwe yakabvumidza kuyedzwa pamwe chete neazithromycin iyo yakatemerwa New York. Zvichakadaro, vezvehutano pasi rose, kusanganisira Anthony Fauci, mukuru weUS National Institute of Allergy and Infectious Diseases, vari kukurudzira kungwarira nezve mishonga iyi.

"Zvizhinji zvezvinhu zvaunonzwa kunze uko ndizvo zvandakanga ndadaidza nhoroondo dzeanecdotal," Fauci akadaro mumusangano wevatori venhau neMugovera weWhite House coronavirus task force. "Basa rangu kuratidza pasina kupokana kuti mushonga hauna kuchengetedzeka chete, asi kuti unoshanda."

Rondedzero yechloroquine yakatanga nezvidzidzo zvidiki zvinoverengeka zvinobva kuChina neFrance — zvese izvi zvine zvikanganiso uye zvinopa zvidzidzo zvishoma kune varwere zvakanyanya. Mhedzisiro yeFrance yakavakirwa pavanhu makumi matatu nevatanhatu chete uye inotarisisa pahutachiona hwevarwere, kana huwandu hwehutachiona mumuviri. Chokwadi, ivo chete varwere kufa kana kuendeswa kunzvimbo yekutarisirwa zvakanyanya muchidzidzo cheFrance vakatora hydroxychloroquine.

"Hatina ruzivo kubva kumiedzo yakasarudzika, inodzorwa inotitaurira kuti chloroquine yakashanda sei muvanhu chaivo," anodaro Annie Luetkemeyer, nyanzvi yeHIV nezvirwere zvinotapukira paUniversity yeCalifornia, San Francisco, Dhipatimendi reMishonga.

Kuzvipa mishonga ine hydroxychloroquine uye azithromycin kune avo vanorwara neCOVID-19 coronavirus inogona zvakare kuuya nenjodzi, sezvo madhiragi maviri aya anogona kumanikidza moyo nekuwedzera njodzi ye arrhythmia. NeMuvhuro, purezidhendi akapikira kutumira New York zviuru zvemadhodhi echikamu chebvunzo yeDAA, nguva pfupi mushure mekunge chipatara cheArizona chazivisa kuti mumwe wevarwere vafa mushure mekuzvirapa pachiroroquine phosphate, fomu yekomboni inoshandiswa kuchenesa aquarium Matangi. Vakuru vezvehutano veNigeria vakataura zviitiko zviviri zvechloroquine overdoses mukupera kwesvondo.

"Chinhu chekupedzisira chatinoda izvozvi kufambisa madhipatimendi edu ekukurumidzira nevarwere vanofunga kuti vakawana mhinduro isina kujeka uye ine njodzi inogona kuisa hutano hwavo panjodzi," Daniel Brooks, director wezvekurapa weBanner Poison uye Drug Information Center muPhoenix , anodaro mune chirevo.

Mishonga YOKUDZIDZA ROPA YAKachengeteka Here?

ACE inhibitors, zvinodhaka zvinoshandiswa zvakanyanya kurapa kukwirisa kweropa, zvakauyawo mumoto panguva yedambudziko re COVID-19, paine mimwe mishumo inoratidza kuti varwere vanofanirwa kurega kutora mishonga iyi kana vaine zviratidzo.

Mune akateedzana tsamba muBritish Medical Journal, Nature Ongororo Cardiology, uye The Lancet Respiratory Medicine, vaongorori vakamutsa mibvunzo pamusoro pekuti ACE inhibitors inogona kubatsira kumisikidza hutachiona hwecoronavirus mumapapu evanhu. Kunetsekana kunobva pakuti SARS neiyo coronavirus nyowani inopinda mumaseru nekunamatira kune protein inonzi angiotensin-inoshandura enzyme 2, kana ACE2 kwenguva pfupi. Protein inowanda pamusoro pemasero emoyo nemapapu, uko kunobatsira kudzora mahormone anokanganisa kukanganiswa kweropa.

Imwe mhedzisiro yeACE inhibitors ndeyekuti vanogona kukurudzira maseru kuti aite yakawanda ACE2. Chidzidzo cha2005 chakawana humbowo hwekuwedzera kwakadaro mumakonzo, uye ongororo ya2015 muvanhu yakawana kuwanda kwemazinga eCE2 mumurini wevarwere vaitora mushonga une hukama neACE inhibitors.

Asi hapana humbowo hwazvino hwekuti ACE inhibitors inoshatisa mhedzisiro yeCOVID-19 muvanhu, sekureva kweAmerican Heart Association, European Society yeCardiology's Council paHypertension, uye ongororo yaKurume 20 yakaburitswa muEuropean Heart Journal. Mazano ekunyanyisa evanachiremba ndeekuti kana iwe wakapihwa mushonga, ramba uchinwa kusvikira waudzwa neimwe nzira nachiremba wako.

"Hatifanire kunge tichitanga kana kumisa iyi mishonga kusvikira tave neruzivo rwakawanda," anodaro Luetkemeyer.

Vanhu vane yakakwira BP uye chirwere chemwoyo vanoita kunge vari panjodzi yakakwira yeCOVID-19, asi izvo zvingangodaro zvine chekuita nezvirwere zviri pasi pazvo. Uyezve, ACE inhibitors inogona kunge iine anti-kupisa zvivakwa, izvo zvinogona kubatsira mapapu evarwere veCOVID-19 zvirinani kurarama nehutachiona. (Dzidza maitiro aya mamiriro ezvinhu anoita kuti coronavirus iwedzere kuoma.)

"Icho chingave chakakosha kudzidza, kuenzanisa vanhu vane BP uye kuwedzera kana kubvisa mishonga iyi, kuona kana paine mutsauko," anodaro Perlman. "Asi zvingave zvakaoma kwazvo kuzviita, uye pamwe zvakaoma kwazvo kupembedza."

NGUVA YEKUTSVAKA CHIPATARA

"Nezvose zvaunogona, kana uine zviratidzo zvekufema zvechimbi-chimbi kana chimwe chinhu chiri kunetsa, tinoda kuti utsvage rubatsiro rwechimbi-chimbi," anodaro Purvi Parikh, nyanzvi yezvirwere zvehutachiona uye zvinotapukira kuNYU Langone muNew York City. Kana iwe ukasarudza kutsvaga rubatsiro kuchipatara chemuno, heino mumwe muenzaniso wezvaunogona kutarisira.

Pachipatara cheIvava Health System chiri muFairfax, Virginia, vashandi vakagadzira tende rekunze kupatsanura vanhu vanotaura nezvezvirwere zvekufema kubva kune vamwe vane zvimwe zvirwere. Iwo mapoka maviri anogadziriswa mumativi akasiyana eiyo imba yekumirira, akapatsanurwa neinenge matanhatu tsoka yenzvimbo.

Nekuda kwekushomeka kwemiyedzo kuUS, vanachiremba kuInova nezvimwe zvipatara vanoti kana vanhu vakasvika vaine zviratidzo zvishoma, varwere ava vanoudzwa kuti vafunge kuti vane COVID-19 uye vanokurudzirwa kuzvisarudzira vega kudzivirira kuremedza nyika irinenge 920,000. mibhedha ine vashandi.

Kune avo vanorwara neCOVID-19 coronavirus uye vari kusvika nezviratidzo zvakakomba sekutadza kufema, vashandi vezvehutano vanotanga nekutarisa pamazinga emweya wemurwere, BP, uye huwandu hwemvura mumapapu avo - zvese izvi vachiedza chengetedza mamiriro avo akadzikama. Ivo zvakare vanoedza kubata fivha, iyo inogona kukonzeresa kusagadzikana uye inotungamira kukuvadzwa kwesero.

Zviitiko zvakanyanya zvakanyanya zveCOVID-19 zvinoda kuisa murwere pamushini wekufema - chishandiso chinotenderera mweya mukati nekubuda mumapapu emunhu - kweinopfuura vhiki imwe panguva. Ndosaka vakuru vehutano vari kunetsekana nekushomeka kwemhepo inouya. Sosaiti yeCritical Care Medicine inoti inosvika mazana maviri ezviuru zvemhepo zviripo muzvipatara zveUS, asi vamwe vakura uye vangangotadza kurapa COVID-200,000. Zvichakadaro, kumwe kufungidzira kwakashata kunoratidza kuti vanopfuura mazana mapfumbamwe ezviuru vekuAmerica vanogona kuwana COVID-19 uye vanoda mweya wekufema.

Mhosva dzakaipisisa dze COVID-19 dzinogona kukonzeresa pane izvo zvinonzi chakanyanya kufema kushungurudzika chirwere (ARDS), kukuvara kwemapapu kwakakomba kunogona kukonzerwa nemhando dzakawanda dzehutachiona hwakanyanya. Zvipatara zvine nzira dzakanyatsotsanangurwa dzemabatiro eARDS. Varwere vanofanirwa kuiswa padumbu ravo kunatsiridza kugona kwemapapu kufefetedza, uye kwete kupihwa mvura yakawandisa. Uye zvakare, maAIRDS evhiringidzi evarwere anofanirwa kuiswa kuti atenderedze mavhoriyamu ezasi emhepo, kudzikisira kushushikana pane alveoli, mapapu 'madiki emakamuri.

Mukati memakamuri echipatara, vashandi vari kutarisira kudzikisa mashandisiro emidziyo inogona kuburitsa madonhwe ekufema, senge michina yekutsigira mweya inosundira mweya mumapapu. Zvimwe zvipatara zviri kushandisa chenjera zvakanyanya nemidziyo inonzi nebulizers, inoshandura mishonga yemvura kuita mhute inofema, sezvo mhute inogona kusimudza SARS-CoV-2 pamusoro. (Ndicho chikonzero nei sipo inosarudzika kuita bleach mukurwisa coronavirus.)

DAMBUDZIKO RINOVIMBISA KURE?

Vanotsvagisa uye varapi kutenderera pasirese vava kumhanyisa kuyedza nemazvo kuti mishonga ingangodaro iriko ingavharirwa muhondo yekurwisa COVID-19. Vanachiremba vakabvunzurudzwa neNational Geographic vakaratidza tariro yakanyanya pamusoro pekugadziriswa, mushonga unorwisa hutachiona urikugadziridzwa neSainzi Sayenzi.

"Mumwe chete wandinoturika ngowani yangu ndeye remdesivir," anodaro Perlman.

Remdesivir inoshanda nekuteedzera chivakwa chevirusi RNA, ichikanganisa hutachiona kugona kuwedzera. Imwe ongororo yakajairika kuChina, yakaburitswa muna Kukadzi 4 muCell Research, yakashuma kuti remdesivir yakavhiringidza kudzokororwa kweSARS-CoV-2 murabhoritari. Asi mushonga uyu uchiri kuyedza uye wakasangana nezvipingaidzo munguva yakapfuura. Remdesivir yakatanga kugadzirirwa kurwisa Ebola, asi kiriniki yayo miedzo muvanhu yakazokundikana.

Zvisinei, kutsvaga kurapa kunoshanda kunoda kutongwa zvine hungwaru miedzo yemakiriniki, zvinotora nguva kuti zviitwe. "Mukutarisa kumashure, zvaizenge zvakanaka dai isu takaisa kumwe kuedza mukuedza anti-coronavirus zvinodhaka," Perlman anowedzera. "Zviri nyore kutaura izvozvi, asi mwedzi mishanu yapfuura, hazvisi nyore."