Itsva Dhata paWarm Antibody Autoimmune Hemolytic Anemia

Rigel Pharmaceuticals, Inc. nhasi yakazivisa kuburitswa kwedata muAmerican Journal yeHematology kubva kune yakavhurika label, multicenter, Phase 2 yekiriniki yekuongorora fostamatinib muvakuru vane inodziya antibody autoimmune hemolytic anemia (wAIHA) akange atadza kamwechete kurapwa kwekutanga. Iyo data yakabudiswa inoratidza kuti fostamatinib, an oral spleen tyrosine kinase (SYK) inhibitor, nekukurumidza uye nekugara yakawedzera hemoglobin (Hgb) mazinga, ine zvine musoro mhinduro yeHgb inocherechedzwa munenge hafu yevarwere, uye kuchengeteka uye kushivirira chimiro chinoenderana nezviripo. fostamatinib kuchengetedza dhatabhesi yevarwere mukati mezvirongwa zvezvirwere zvakawanda zvakadzidzwa. Bhuku racho, rine musoro unoti "Fostamatinib for the treatment of warm antibody autoimmune hemolytic anemia: Phase 2, multicenter, open-label study", rinowanikwa pawebsite yejenari.

"Migumisiro yakaonekwa muChidzidzo chedu cheChikamu chechipiri mukudziya kwe autoimmune hemolytic anemia inosimbisa kugona kwe fostamatinib kubatsira varwere vane chirwere ichi chisingawanzoitiki, chakakomba cheropa avo vasina kurapwa kwakanangana nechirwere kunobvumidzwa," akadaro Raul Rodriguez, mutungamiri weRigel uye mukuru mukuru. officer. "Kana ikabvumidzwa, fostamatinib ine mukana wekuve wekutanga-ku-musika kurapa kune varwere vane wIHA muna 2 uye ingave yechipiri yakatenderwa chiratidzo chefostamatinib."

The Phase 2 yekudzidza yakaongorora mhinduro kune fostamatinib pa 150 mg BID (kaviri zuva nezuva) muvarwere vakuru vane wAIHA uye inoshingaira hemolysis neHgb isingasviki 10 g / dL avo vakanga vakundikana kamwe chete kurapwa kwekare. Mhedziso yekutanga yaiva Hgb yakakura kudarika 10 g / dL nekuwedzera kwe ≥2 g / dL kubva pakutanga neSvondo 24 pasina kuponesa kurapa kana kuwedzerwa kweropa tsvuku. Chidzidzo chacho chakaratidza kuti 46% (11/24) yevarwere vakawana magumo ekupedzisira, uye 1 anononoka kupindura pavhiki 30 (huwandu hwevane 12 vanopindura [50%]). Kuwedzera kwepakati Hgb kwakaonekwa paVhiki 2 uye kwakatsigirwa nekufamba kwenguva. Zviitiko zvakanyanya kuipa (AEs) manyoka (42%), kuneta (42%), hypertension (27%), chizuru (27%), uye kushaya hope (23%). MaAE aigoneka uye aienderana nefostamatinib yekuchengetedza dhatabhesi yevarwere vanopfuura zviuru zvitatu nemazana mapfumbamwe pazvirwere zvakawanda (rheumatoid arthritis, B-cell lymphoma, COVID-3,900, uye immune thrombocytopenia (ITP)). Hapana zviratidzo zvitsva zvekuchengetedza zvakaonekwa.