“Chikwata cheSNIPR BIOME chiri kufara nechiitiko chakakosha ichi, uye tiri kutarisira kutanga kuyedza kukiriniki kuUS gare gare gore rino, tichiyedza tekinoroji yedu yeCRSPR. SNIPR001 ndiyo pfuma yedu yakafambira mberi zvikuru, uye tinodada nekuedza kwechikwata kwatiunza pano” anodaro Dr. Christian Grøndahl, Co-founder & CEO.
Muedzo wekiriniki unogona kugadzirira nzira yemhando itsva yekurapa kwakanyatso kusarudzwa kuti inange E. coli muvarwere vegomarara vane hematological malignancies - ari magomarara anokanganisa ropa, mwongo, uye lymph nodes. Varwere ava vari pangozi yekuwedzera kwehupenyu hwehutachiona hwehutachiona hunokonzerwa nechirwere, kune chemotherapy kurapwa uye, zvakakosha, kune pathogen translocation kubva mumatumbo, umo E. coli mumwe wevatambi vanokosha mukukonzera utachiona.
SNIPR001 ine chinangwa chekunangisa E. coli bacteria muura, uye nekudaro kudzivirira kutapurirana kwemabhakitiriya aya kuenda kuropa, uku ichisiya mabhakitiriya ecommensal mumicrobiome yemurwere asina kubatwa. Iyo nzira neSNIPR001 iri kushandisa rivhisi rekushandisa tekinoroji yedu yeCRSPR/Cas kuti zvisarudze kubvisa E. coli mabhakitiriya kubva mumatumbu. Iyi nzira chaiyo inogona kushandura nzira iyo E. coli inodzivirirwa nekurapwa nayo, kunyanya muwadhi yegomarara.
Nhasi, hapana marapirwo anotenderwa eprophylactic therapy mune ino marongero.
"Kubva pane yedu pre-kiriniki data neSNIPR001 isu tinotenda kuti tekinoroji yedu ine mukana wakakura mukugadzira mangwana-based CRISPR mishonga yekurwisa zvirwere zvinouraya uye kugadzirisa zvirwere zvinoenderana nemicrobiome" anodaro Dr. Milan Zdravkovic, Chief Medical Officer uye Head yeR&D paSNIPR Biome. "Nekukwira kwekurwisa hutachiona hwehutachiona pane kudiwa kwekukurumidzira kwevanoda kutora mishonga yekurapa mabhakitiriya anotapukira, seE. coli, uye tinotenda nekubatana nesangano risingabatsiri, CARB-X paSNIPR001".
SNIPR001 ndiyo yekutanga yevakawanda vanogona kurapwa, sezvakasimbiswa naDr. Christian Grøndahl: "Tiri kuvaka pombi yakasimba yezvinonzi CRISPR assets uye tine zvinopfuura kufarira kwedu zvirwere zvinotapukira, kudyidzana neMD Anderson Cancer Center pa immuno-oncology, uye neNovo Nordisk pakushandisa gene-modulation tekinoroji pane iyo microbiome. Isu tinofara kuongorora kugona kwakazara kweiyo CRISPR tekinoroji mune ramangwana ".
ZVOKUBVA MUNYAYA INO:
- "Tiri kuvaka pombi yakasimba yeinoveli CRISPR midziyo uye tinopfuura kufarira kwedu zvirwere zvinotapukira, kudyidzana neMD Anderson Cancer Center pa immuno-oncology, uye neNovo Nordisk pakushandisa gene-modulation tekinoroji pamicrobiome.
- coli mabhakitiriya mudumbu, uye nekudaro kudzivirira kutamiswa kweaya mabhakitiriya kuenda kuropa, uku achisiya mabhakitiriya ecommensal mumicrobiome yemurwere asina kubatwa.
- Varwere ava vari panjodzi yekuwedzera kwehupenyu hwehutachiona hweropa nekuda kwechirwere, kurapwa nechemotherapy uye, zvakakosha, kutakurwa kwepathogen kubva muura, umo E.
