Anacardium occidentale (Ao), muti wakajairika wecashew, chirimwa chakagara chichizivikanwa mumasystem emishonga yechivanhu nekuda kwekugona kwayo kwekurapa. Semuenzaniso, zvikamu zvakasiyana-siyana zvemuti uyu wemunzvimbo dzinopisa dzepasi, mashizha, makwati, tsanga dzemhodzi, uye chingamu, zvinozivikanwa kuti zvine simba rekurwisa manyoka. Zvisinei, maitiro chaiwo echiito anoramba ari chakavanzika.
Dr. Kayode E. Adewole kubva kuYunivhesiti yeMedical Sciences, Nigeria, uye vaaishanda navo vakaedza kusanzwisisa maitiro kuburikidza nekuongorora basa rekurwisa manyoka re stem bark extract yemiti yemacashew. Maonero avo anovimbisa achangobva kuburitswa mu Journal of Pharmaceutical Analysis.
Inokonzerwa nezvinhu zvakasiyana-siyana sekusashivirira kwechikafu, hutachiona hwehutachiona, zvinodhaka, uye kusagadzikana kwematumbo, manyoka idambudziko guru rehutano hweveruzhinji, uye rinokonzera kufa kwakanyanya kwevana. Kazhinji, chirwere chinoratidzika sekuwedzera kwehutu motility. Kuti uongorore iyo anti-manyoka maitiro ecashew stem bark inobvisa, vaongorori vakatarisa nzira dzemaserura uye makiyi mamorekuru vatambi vanobatanidzwa mune abnormal gut motility uye vakagadzira nhevedzano yebvunzo-yakavakirwa mulabhu.
Dr. Adewole anotsanangura kuti, "Manyoka anokonzerwa nekuwedzera kutsetseka kwemhasuru yehuku, iyo inowanzodzorwa nenzira nhatu neurophysiological pathways, dopaminergic, cholinergic, uye serotonergic. Naizvozvo, maitiro edu ekuyedza aive ekukurudzira zvegastric motility kuburikidza neimwe yenzira idzi uye tozoona kuti ndeipi yeiyi yakadziviswa necashew stem bark inobvisa. Kuedza kwedu kwakakamurwa kuita zvikamu zviviri, mu vivo, yakaitwa mumakonzo mhenyu, uye in vitro, yakaitwa pamasero emudumbu.
Chikwata ichi chaishandisa gastrointestinal motility-inducing zvinodhaka, zvinoti metoclopramide (a dopamine receptor antagonist), carbachol (an acetylcholine receptor agonist), uye serotonin (iyo inokurudzira serotonergic receptors), kuparadzanisa mapoka emakonzo. Mamwe mapoka matatu akagamuchira mishonga yakafanana asi yakagadziriswa necashew stem bark extract.
Vakaona kuti chidimbu chakagadzirwa ethyl acetate cheyakatorwa (chakanyorwa AoEF) chakanyanya kuvharidzira nzira yecholinergic yekubvisa gastric uye kubuda kwegastrointestinal asi haina mhedzisiro pane dzimwe nzira mbiri, ichipa nzwisiso iri nani mumagadzirirwo echiito.
Sechikamu chezviyedzo zve in vitro, vaongorori vakatsaura mitsetse kubva muura hweguinea pigs uye vakawana kuti pakakwirira, AoEF inobudirira uye nekudzoreredza tambo iyi. Izvi zvakaonekwa kunyangwe mumitsetse yaive isati yarapwa neAoEF ndokuzobatwa neprokinetic mamorekuru se histamine, serotonin, uye acetylcholine.
Kupfuurirazve, vachishandisa gasi chromatography-mass spectroscopy, timu yakaona zvikamu makumi maviri nemana zviripo muAoEF. Zvidzidzo zveBioinformatics-based zvakaratidza kuti pakati pemakomponi aya, octadecanoic acid 24- (2-hydroxylethoxy) ethyl ester yaive nepamusoro inosunga hukama kune muscarinic acetylcholine receptor M2 (CHRM3). Izvi zvakabvumira boka kuti ribatanidze pamwe chete humbowo kubva kune ese akasiyana kuyedza uye kusvika pane inogoneka maitiro echiito chezvakatorwa.
Kubatanidza simba reruzivo rwechinyakare uye sainzi yemazuva ano, Dr. Adewole neboka rake vari kutarisira kuti kuwanikwa kwavo kuchakurudzira kuumbwa kwemishonga mitsva yakaderera yekurapa nekugadzirisa manyoka.
ZVOKUBVA MUNYAYA INO:
- Vakaona kuti chidimbu chakagadzirwa ethyl acetate cheyakatorwa (chakanyorwa AoEF) chakanyanya kuvharidzira nzira yecholinergic yekubvisa gastric uye kubuda kwegastrointestinal asi haina mhedzisiro pane dzimwe nzira mbiri, ichipa nzwisiso iri nani mumagadzirirwo echiito.
- To explore the anti-diarrheal mechanism of cashew stem bark extract, the researchers focused on the cellular pathways and key molecular players involved in abnormal gut motility and designed a series of lab-based experiments.
- As part of the in vitro experiments, the researchers isolated strips from the intestine of guinea pigs and found that at a higher concentration, AoEF efficiently and reversibly relaxed these strips.
