New therapy chikuva chekushandura kurapwa kwemamota akasimba

A2 Biotherapeutics, Inc., kambani yebiotechnology yakatarisana nekurapwa kwemamota akasimba, yakazivisa nhasi kuti kiyi preclinical data ine chekuita neyayo Tmod ™ cell therapy chikuva yakaburitswa muScience Translational Medicine uye Journal yeImmunoTherapy yeCancer. Tmod ™ kurapa kwakagadzirirwa varwere vegomarara vane mabundu ane zvakadzimwa genetic, uye kuongororwa kwemajini kunogonesa kuzivikanwa kwekutanga kwevarwere vanogona kubatsirwa kubva mukurapwa kwakadaro. Tmod ™ therapy inoshandisa kudzima kwakadaro kuti iparadze mabundu zvine rusaruro uchichengetedza masero akajairwa, zvichikwanisa kupa nzira nyowani yekurapa zvakachengeteka uye zvinobudirira magomarara akasimba emamota.             

"Mapepa maviri aya anopa huwandu hukuru hwe preclinical in vitro uye in vivo humbowo hunotsigira yakasimba, yakasarudzika basa reTmod ™ system, nzira nyowani yekurapa cancer inogadzirisa musoro-pane dambudziko repakati reoncology - kugona mishonga yegomarara kusiyanisa bundu nemasero akajairwa,” akadaro Dr. Alexander Kamb, Chief Scientific Officer paA2 Bio.

Bepa rakaburitswa munaKurume 2, 2022 muScience Translational Medicine (Sandberg et al., "Sero rekurapa rakagadzirirwa kunangana neECA antigen zvakachengeteka muvarwere vakasarudzwa vane mamota akasimba") rinotsanangura mumiriri wekiriniki anonangidzirwa kumamota akasimba emukoloni uye mamwe. nhengo dziri kuenda kuChikamu 1. Dr. Han Xu, Mutevedzeri weMutungamiriri weTherapeutic Technology paA2 Bio uye munyori mukuru pabepa, akati: "Data yedu yepreclinical inoratidza kuti mushonga uyu unogadzirwa nesero uchave uine simba rekiriniki. inoshanda CEA-yakanangana nekurapa bhenji, asi isina chepfu. "

Pepa rakaburitswa muna Ndira 28, 2022 muJournal yeImmunoTherapy yeCancer (Tokatlian et al., "Mesothelin-specific CAR-T cell therapy iyo inosanganisira HLA-gated kuchengetedza nzira inouraya masero emamota") inoratidza zvingangoita mashandisirwo eTmod. ™ T masero mukenza yemapapu uye mamwe mamota akasimba. Dr. Agi Hamburger, Mutevedzeri weMutungamiriri weDrug Discovery uye munyori mukuru, vakati: “Chinyorwa chedu hachingotsananguri hunhu hwetarisiro itsva inonakidza yevarwere vekenza yemapapu asiwo rinosimbisa kuorora kunoshamisa kwepuratifomu yedu yeTmod™, chikuva chatinoda. tariro inogona kuwedzerwa kugadzira marapirwo evamwe varwere vegomarara mune ramangwana. "