Imwe nhanho padhuze nekurapa kutsva kweCystic Fibrosis

Entrinsic Bioscience uye ane rezinesi reNuvara Therapeutics yakazivisa kuti idanho rimwe padyo nekushandisa RxAA maumbirwo semurapi wevarwere vane Cystic Fibrosis Kirasi I shanduko. Muongorori weYunivhesiti yeFlorida Dr. Sadasivan Vidyasagar, muvambi uye sachigaro webhodhi rekambani yemazano ezvesainzi, munguva pfupi yapfuura akagovera imwe nzira yekudzoreredza airway anion secretion pamusangano weExperimental Biology 2022 wakaitirwa muPhiladelphia.      

Vidyasagar nechikwata chake, icho chaisanganisira vaongorori veUF uye Entrinsic Bioscience, vakaratidza kuti Nuvara's VS-009 formula inogona kubatsira kune varwere vane Cystic Fibrosis Kirasi I shanduko pamwe neKirasi II uye III shanduko. Mushonga wacho unogona kushandiswa wega kana musanganiswa nemamwe marapirwo ekuvandudza kugadzirwa kwechloride.

Stephen J. Gatto, Sachigaro Mukuru weNuvara Therapeutics, akakorokotedza Astrid Grosche nevamwe vese vechikwata chaDr. Vidyasagar nekuenderera mberi kwavo nekuzvipira mukutyaira nzira dzekuongorora mashandiro ekufema epithelial.

"Ndinoda kutenda Astrid, Dr. Vidyasagar nevamwe vose veboka rake nokuda kwekuzvipira kwavo kusinganeti kugadzirisa kuchinja kweClass I muCystic Fibrosis, shanduko inogona kukanganisa kusvika ku18% yehuwandu hweCF," akadaro Stephen J. Gatto.

"Izvi zvinyorwa zviviri zvinoratidza kuti ion-channel manipulation inogoneka mukufema epithelium uchishandisa akarongedzerwa maumbirwo emaamino acids," akaenderera mberi Gatto. “Ion-channel dysfunction ndiyo iri pakati pezvirwere zvakawanda, zvakaita seCF uye zvirwere umo mune kuwedzera kwekugadzirwa kwemucus, zvinosanganisira asthma neCOPD. Aya maitiro / marapirwo anozotitendera kuti tigadzirise kuwanda kweiyoni uye mvura mukati menzira yemhepo padanho remaserura ine mishoma mhedzisiro.

"Pachine basa rinofanira kuitwa, asi mukana wacho unonakidza uye unogona kumiririra kubudirira mukutonga kwechannelopathies nezvirwere zvinoenderana," akadaro Gatto.

Vidyasagar akapawo poster pachishandiso chaakagadzira lab yake kuyera zvirinani intestinal peristalsis uye kupindirana kwe intraluminal pressure, kudhonzwa kwemhasuru, uye shanduko yehuwandu hwemvura.

"Izvi zvinyorwa zviviri zvakasiyana pakuti zvinoratidzira kukwanisa kugadzirisa epithelial transmembrane proteins (eTMPs) nesarudzo yakasarudzwa yeamino SAA (RxAAs)," akadaro Dr. William Denman, Chief Medical Advisor kuNuvara Therapeutics. "Izvi zvinovhura musuwo wekurapa kunoshanda, kusiri muchetura padanho rekutanga remaserura, zvisinei neiyo etiology."

Dr. Denman vakaenderera mberi vachiti, “Mishonga yeramangwana inogona ikozvino kurongerwa uye kurongedzerwa chiteshi chega chega uye chirwere - mushonga chaiwo wemunhu. Basa rakawanda rinodiwa, asi izvi zvinogona kubvumidza dzimwe nzira dzekurapa padanho remaserura mukati mezvirwere zvakasiyana-siyana zvine mhedzisiro shoma. "

Entrinsic Bioscience ndeye UF yekutanga iri muUF Innovate | Kurumidza kuSid Martin Biotech muAlachua. Iyo kambani iri kugadzira zvese-zvakasikwa, glucose-isina maumbirwo ekiriniki hydration, hutano hwematumbo uye hutano, allergies, uye kuchengetedza ganda.