"Plaque psoriasis inogona kuisa mutoro wakakura pahupenyu hwevarwere, zvisinei nekuoma kwekubatanidzwa kweganda. Chido chikuru chisingakwaniriswe chinoramba chiri chevarwere vakapfava kusvika pakati nepakati avo vangave vasina kukwana kurapwa kwemusoro, kunyanya kune avo vane nzvimbo dzakaoma-kurapa, semumusoro," akadaro David M. Reese, MD, mutevedzeri wemutungamiri weResearch. uye Budiriro paAmgen. "Nechiratidzo chakawedzerwa ichi cheOtezla, varwere vari mumatunhu ese ekuomarara kwechirwere zvino vava nemuromo, systemic sarudzo yakatoshandiswa nevanhu vanopfuura 650,000 pasi rese uye haina chinodiwa chekutarisa lab."
"Tichifunga kuti psoriasis ndeye systemic inflammatory disease, vamwe varwere vangada zvinopfuura kusunungurwa kwepamusoro," akadaro Dr. Linda Stein Gold, mutungamiriri weDermatology Clinical Research paHenry Ford Health System, Detroit, uye ADVANCE muongorori. "Kekutanga, vanachiremba vedermatologist vanogona kupa varwere vari kunetsekana neplaque psoriasis yechero dhigirii kurapwa kunoshanda kwemukanwa ine yakasimbiswa yekuchengetedza nhoroondo."
Mvumo yeFDA yakavakirwa pane zvakawanikwa kubva muyedzo yePhase 3 ADVANCE, umo kakapetwa kashanu vanhu vakuru vazhinji vane nyoro kusvika pakati nepakati plaque psoriasis vanogamuchira oral Otezla 30 mg kaviri zuva nezuva vakawana magumo ekutanga eStatic Physician's Global Assessment (sPGA) mhinduro pavhiki 16. zvichienzaniswa ne placebo (21.6% inopesana ne4.1%, p <0.0001), mutsauko waive wakakosha. Otezla yakaratidzawo kuvandudzwa kwakakosha muzviratidzo zvakakosha, senge Whole Body Itch NRS mhinduro (43.2% inopesana ne18.6%), uye nzvimbo yakaoma-kurapa, iyo scalp, yakayerwa neScalp Physician's Global Assessment (ScPGA) mhinduro (44% maringe ne16.6%), pavhiki 16 zvichienzaniswa ne placebo. Kuvandudzwa kwemhinduro ye sPGA, Muviri Wese Itch NRS uye ScPGA mhinduro yakaonekwa sekutanga kwevhiki 2 uye yakachengetwa kuburikidza nevhiki 32.
Zviitiko zvakashata zvakaonekwa muyedzo zvaienderana neyaizivikanwa chengetedzo mbiri yeOtezla. Zviitiko zvinonyanya kutaurwa (≥5%) zvekurapa-zvinoitika zvakashata neOtezla kurapwa kwaive manyoka, kutemwa nemusoro, kuda kurutsa uye nasopharyngitis.
Vanosvika mamirioni masere vanhu muUS vane plaque psoriasis, uye 8 miriyoni vanhu muUS vane hunyoro kusvika pakati nepakati chirwere. Zvisinei nekuwanda uye kufambira mberi kwekurapa mumakore achangopfuura, chinodikanwa chakakosha chichiripo, kunyanya kune vanhu vane hunyoro kusvika pakati nepakati plaque psoriasis kana avo vanoramba vachiona zviratidzo kunyangwe kurapwa kwepamusoro.
"Plaque psoriasis inowanzobata varwere zvakanyanya kupfuura inogona kuyerwa neBody Surface Area chete, kunyanya kune avo vane zviratidzo munzvimbo dzakaoma-kurapa semumusoro. Nzvimbo yezvikwangwani inogona kuita kuti nzvimbo iyi inzwe kubatwa nemishonga kana kuti inonetsa kuashandisa,” akadaro Stacie Bell, Ph.D., mukuru wesainzi uye wezvekurapa kuNational Psoriasis Foundation. "Nhau dzinogamuchirwa kuti pakupedzisira uve nemuromo systemic sarudzo ine yakanyatsosimbiswa yekuchengetedza mbiri inowanikwa kune vese vakuru plaque psoriasis varwere."
Otezla inotenderwa zviratidzo zvitatu muUS, kusanganisira varwere vakuru vane plaque psoriasis vari kuda kutora phototherapy kana systemic therapy, varwere vakuru vane active psoriatic arthritis uye kuvarwere vakuru vane maronda emukanwa ane chekuita neBehçet's Disease. Otezla ndiyo inonyanya kunyorerwa mhando ye plaque psoriasis varwere vanotanga systemic therapy.3 Amgen yakazvipira kuongorora zvingaita zveOtezla kumativi ose ekuenderera mberi kwe psoriasis, kusanganisira varwere vasina kuchengetwa vane genital psoriasis, pediatric psoriasis, juvenile psoriatic arthritis nedzimwe nzvimbo dzine mutoro mukuru.
