Tsvagiridzo Itsva Yekurapa kwePancreatic Cancer

Loki Therapeutics nhasi yakazivisa zvinyorwa zvekutsvaga mumagazini, "Science Translational Medicine", ichiratidza kukwanisa kweAWAKE-LM-TT mukurapa kenza yepancreatic. AWAKE-LM-TT, yakagadzirwa naClaudia Gravekamp, ​​Ph.D., Loki's Co-Founder uye Associated Purofesa weMicrobiology & Immunology paAlbert Einstein Chikoro cheMishonga, inokoshesa mujekiseni wehucheche hwetetanus kugadzira simba rekudzivirira muviri nekukurumidza. mhinduro kumamota akasimba uye metastases inopa tetanus antigens.

Chinyorwa chine musoro, "Listeria Inoendesa Tetanus Toxoid Protein kune Pancreatic Tumors uye Inokonzera Cancer Cell Rufu muMbeva," uye yakanyorwa pamwe naDr. Gravekamp, ​​Ph.D., inotsanangura tsvakiridzo inosanganisira nzira itsva yekurapa gomarara repancreatic iro Listeria monocytogenes iri. inoshandiswa kuendesa yakanyanya immunogenic tetanus toxoid (TT) mapuroteni akananga mumamota masero. Kuburitswa uku, Listeria-TT, kwakaratidzwa kuita kuti immune system ipindure, ichiita tetanus toxoid-specific memory T masero kuuraya pancreatic ductal adenocarcinoma (PDAC) tumor cell mumakonzo. Kana yasanganiswa ne gemcitabine (Listeria-TT + GEM), vatsvakurudzi vakaona kuderedzwa kwe80% kwePDAC bundu mutoro uye kuderedzwa kwe87% kwemasastases nekuwedzera kwehupenyu ne 40% kana ichienzaniswa nembeva dzisina kurapwa, zvichiratidza kuti Listeria-yakanunurwa inoyeuka maantigens inogona kuva. imwe nzira kune neoantigen-mediated cancer immunotherapy.

Loki Co-muvambi uye CEO Chris Bradley akati, "Chidzidzo ichi chinongova chidimbu chechando kana tasvika pakuziva nekutsvaga marapirwo anoshanda ekurapa gomarara rakaoma. Pancreatic cancer inonetsa kuziva padanho rekutanga, izvo zvinoita kuti kutsvaga kurapwa kunyanye kunetsa, nekuti inowanzoonekwa padanho repamusoro kana kunonoka. Tsvagiridzo iyi inoratidza kugona kwakakosha kweLoki's AWAKE-LM-TT semushonga wekurapa gomarara repancreatic yakapihwa kugona kwayo kushandisa jekiseni rehucheche retetanus toxoid kuti ibudise mhinduro ine simba uye nekukasira yekudzivirira kudzivirira kumamota akasimba uye metastases inopa tetanus antigens.

Dr. Gravekamp vakatsinhira vachiti, “Nekuda kwetsvakiridzo iyi, tine hurongwa hutsva husingagone chete kubudirira mukurapa gomarara repancreatic, asi mamwe magomarara zvakare. Pancreatic tumors inonetsa kurapa mukuti, kune immune system, mabundu aya haaratidzike zvakakwana 'ekune dzimwe nyika' kukwezva kutarisisa kwemasoja edziviriro uye anogona kudzvanya chero mhinduro dzedziviriro dzinoitika. Maitiro edu anoita kuti mamota aya 'anotonhora' apise zvakakwana kuti immune system irwise nekuparadza."

Loki ari kugadzirira kuisa chikumbiro cheInvestigational New Drug (IND) neUS Food & Drug Administration yechirongwa chekiriniki chekutanga mumunhu chiri kuongorora AWAKE-LM-TT mukurapwa kwegomarara repancreatic. Pakugamuchira mvumo yeFDA yeIND, Loki anotarisira kutanga chirongwa chekiriniki cheChikamu chekutanga muhafu yechipiri ya1.