New Nasal Spray Yakagadzirirwa Kuuraya COVID-19

Glenmark Pharmaceuticals Limited (Glenmark) - kambani yepasi rose yemishonga - uye yekuCanada kambani yemishonga SaNOtize Research & Development Corp., nhasi yakazivisa kuvhurwa kweiyo Nitric Oxide Nasal Spray pasi pezita rechiratidzo FabiSpray® kuIndia kurapwa kwevarwere vakuru vane COVID-19. avo vane njodzi huru yekufambira mberi kwechirwere. Glenmark akambotambira mvumo yekugadzira nekushambadzira kubva kuDrugs Controller General yeIndia (DCGI) yeNONS sechikamu chekukurumidza kubvumidzwa.

FabiSpray®, Nitric Oxide Nasal Spray, yakagadzirirwa kuuraya hutachiona hweCOVID-19 mumigwagwa yekumusoro. Iyo yakaratidza anti-microbial zvivakwa zvine yakananga virucidal mhedzisiro paSARS-CoV-2. NONS kana yapfapfaidzwa pamusoro penasal mucosa inoita sechidziviso chemuviri nekemikari kurwisa hutachiona, huchidzivirira kuti dzisakura nekupararira kumapapu.

Vachitaura nezvekukosha kwebudiriro iyi, Robert Crockart, Chief Commercial Officer, Glenmark Pharmaceuticals Ltd. akati, "Semutambi anotungamira wemishonga, zvakakosha kuti isu tiri chikamu chakakosha chekurwira India kurwisa denda reCOVID-19. Isu tinofara kugashira mvumo yemutemo yeNitric Oxide Nasal Spray (FabiSpray®) uye kuivhura takabatana neSaNOtize. Izvi zvinosimbisa kuzvipira kwedu kwekupa imwezve yakachengeteka uye inoshanda antiviral kurapa kweCCIDID-19, uye tine chivimbo chekuti ichapa varwere nzira yekurapa inodiwa uye nenguva."

Indian Phase 3 Clinical Trial Outcomes

• Chiyedzo chekiriniki cheChikamu chechitatu chakaitwa muvarwere vakuru veCOVID-3 munzvimbo makumi maviri dzekiriniki muIndia. Iwo maviri-mapofu, ruoko rwakafanana, kudzidza kwakawanda, kwakaitwa muvarwere ve19 vakaongorora kushanda uye kuchengetedzeka kweNitric Oxide Nasal Spray maringe neyakajairwa saline nasal spray muvarwere vakura vasiri muchipatara. Vese varwere vakawana rubatsiro rwakakwana mukudzidza.

• Muedzo wakaongorora varwere vane ngozi yekufambira mberi kwechirwere - varwere vasina kuvharwa, varwere vari pakati neboka rezera rekare uye varwere vane co-morbidities.

• Mhedziso yekutanga yakazadzikiswa: Kuderedzwa kweiyo log viral load muboka reNONS kwaive kwakakosha uye kuri pamusoro peboka rekutonga (placebo) (p <0.05).

• Nguva yepakati pekurapa hutachiona hwaive mazuva mana muboka reNONS uye mazuva masere muboka replacebo (p <4).

• Chiyero chepamusoro chevarwere chakaratidza 2-point yekuvandudza pa WHO Progression Scale (yakagadziriswa kliniki yekupedzisira) muboka reNONS kana ichienzaniswa neboka re placebo (p <0.05).

• NONS yakanga yakachengetedzeka uye yakatenderwa nevarwere. Hapana varwere vakawana zvine mwero, zvakakomba, zvakakomba Zviitiko Zvakaipa (AE) kana kufa muchidzidzo.

Dr. Monika Tandon, Senior VP & Head – Clinical Development, Glenmark Pharmaceuticals Ltd., vakati: “Zvabuda kubva muChikamu chechitatu ichi, chiyedzo chedouble blind, placebo controlled chinokurudzira. Kuratidza kuderedzwa kwehutachiwana hune simba rakanaka kubva kune murwere uye maonero evanhu. Mumamiriro ezvinhu aripo, paine mitsva iri kubuda inoratidza kutapurirana kwakanyanya, NONS inopa sarudzo inobatsira mukurwisa kweIndia kurwisa COVID-3. "

Muna Kurume 2021, miedzo yekiriniki kubva kumugadziri wayo, SaNOtize yakaratidza NONS yaive yakachengeteka uye inoshanda antiviral kurapa kweSARS CoV-2. Mumaawa makumi maviri nemana ekutanga, NONS yakadzikisa avhareji yehutachiwana nezvikamu makumi mapfumbamwe neshanu muzana, uyezve neinopfuura 24% mukati memaawa makumi manomwe nemaviri. (Muyedzo yeIndia Phase 95, kudzikiswa kwehutachiwana hwe99% mumaawa makumi maviri nemana uye 72% mumaawa makumi mana nemasere kwakafanana nekuderedza kunoonekwa muUK NHS kuyedza kwakaitwa neSaNOtize). NONS yakaedzwa mune vanozvipira vane hutano nevarwere sechikamu cheCanada uye UK miedzo yemakiriniki. SaNOtize ine inoenderera mberi yepasirese Phase 3 yekudzivirira kuyedza, iyo inowedzera kuwedzera kune yayo kushanda. Sezvinei zvidzidzo zvakaitwa muUtah State University USA, NONS inoratidzwa kuuraya 94% yehutachiona hweSARS-Cov-24 inosanganisira Alpha, Beta, Gamma, Delta, uye Epsilon musiyano mukati memaminitsi maviri.